Kinetics of Blood-Brain Barrier Transport of Monoclonal Antibodies Targeting the Insulin Receptor and the Transferrin Receptor

Biologic drugs are large molecule pharmaceuticals that do not cross the blood-brain barrier (BBB), which is formed by the brain

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In Vitro Antileishmanial Activity of Achillea santolina Essential Oil against Leishmania infantum Promastigote by Methylthiazole Tetrazolium (MTT) and Trypan Blue Colorimetric Methods

Leishmaniasis causes parasitic infections, especially in developing countries. The disease has not yet been controlled because of the absence of

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Developing more generalizable prediction models from pooled studies and large clustered data sets

Prediction models often yield inaccurate predictions for new individuals. Large data sets from pooled studies or electronic healthcare records may

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Subclinical hypothyroidism is associated with basal ganglia enlarged perivascular spaces and overall cerebral small vessel disease load

Background: The association between subclinical hypothyroidism (SCH) and cerebral small vessel disease (CSVD) in the stroke-free population is currently unclear. Methods: A

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The genetic architecture of resilience highlights the need for precision interventions

Background: Resilience from Alzheimer’s disease (AD) is heritable trait with a largely unexplored genetic architecture. We have developed a harmonized resource

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Subclinical hypothyroidism is associated with basal ganglia enlarged perivascular spaces

Background: The association between subclinical hypothyroidism (SCH) and cerebral small vessel disease (CSVD) in the stroke-free population is currently unclear. Methods: A

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A genome-wide association study explores the genetic determinism of host resistance to Salmonella pullorum infection in chickens.

Salmonella infection is a severe concern in poultry farming as a result of of its influence on each financial loss

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Segregation and potential functional impact of a rare stop-gain PABPC4L variant in familial atypical Parkinsonism.

Atypical parkinsonian problems (APDs) comprise a group of neurodegenerative ailments with heterogeneous scientific and pathological options. Most APDs are sporadic,

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