UBE2K Rabbit Polyclonal Antibody

Description: A polyclonal antibody against UBE2K. Recognizes UBE2K from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:50-1:200, IF:1:50-1:500

Description: A polyclonal antibody against UBE2K. Recognizes UBE2K from Human. This antibody is Unconjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against UBE2K. Recognizes UBE2K from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

Description: Rabbit polyclonal UBE2K antibody

Description: Affinity purified rabbit polyclonal UBE2K antibody

Description: Affinity purified rabbit polyclonal UBE2K antibody

Description: Rabbit polyclonal UBE2K antibody

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human UBE2K (N-term). This antibody is tested and proven to work in the following applications:

Description: Antibody raised against UBE2K

Description: The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene.

Description: The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene.

Description: Unconjugated Rabbit polyclonal to UBE2K

Description: A polyclonal antibody raised in Goat that recognizes and binds to Human UBE2K / LIG (C-Terminus). This antibody is tested and proven to work in the following applications:

Description: A polyclonal antibody against UBE2K. Recognizes UBE2K from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against UBE2K. Recognizes UBE2K from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against UBE2K. Recognizes UBE2K from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against UBE2K. Recognizes UBE2K from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against UBE2K. Recognizes UBE2K from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against UBE2K. Recognizes UBE2K from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Description: A cloning plasmid for the UBE2K gene.

Description: Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with huntingtin, and MHC-heavy chain proteins.

Description: Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with huntingtin, and MHC-heavy chain proteins.

Description: A synthetic peptide for use as a blocking control in assays to test for specificity of UBE2K antibody, catalog no. 70R-9579

Description: A synthetic peptide for use as a blocking control in assays to test for specificity of UBE2K antibody, catalog no. 70R-2724

Description: A synthetic peptide for use as a blocking control in assays to test for specificity of UBE2K antibody, catalog no. 70R-9580

Description: Purified recombinant Human UBE2K protein

Description: Recombinant full length UBE2K (UBC1) protein also known as E2-25K, HIP2, HYPG, LIG, and UB1. Genbank Accession NM_005339, with an N-terminal His-tag, expressed in E. coli cells. MW = 25kDa.

Description: The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene.

Description: Description of target: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.8 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme."_x005F_x005F_x000D_Kalchman M.A., Graham R.K., Xia G., Koide H.B., Hodgson J.G., Graham K.C., Goldberg Y.P., Gietz R.D., Pickart C.M., Hayden M.R._x005F_x005F_x000D_J. Biol. Chem. 271:19385-19394(1996) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.Ref.2"Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis."_x005F_x005F_x000D_Kikuchi J., Furukawa Y., Kubo N., Tokura A., Hayashi N., Nakamura M., Matsuda M., Sakurabayashi I._x005F_x005F_x000D_Arterioscler. Thromb. Vasc. Biol. 20:128-134(2000) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, INDUCTION.Ref.3"Regulation of macrophage-specific gene expression by degenerated lipoproteins."_x005F_x005F_x000D_Furukawa Y., Kubo N., Kikuchi J., Tokura A., Fujita N., Sakurabayashi I._x005F_x005F_x000D_Electrophoresis 21:338-346(2000) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, INDUCTION.Ref.9"NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)."_x005F_x005F_x000D_Yamada M., Ohnishi J., Ohkawara B., Iemura S., Satoh K., Hyodo-Miura J., Kawachi K., Natsume T., Shibuya H._x005F_x005F_x000D_J. Biol. Chem. 281:20749-20760(2006) [PubMed] [Europe PMC] [Abstract]Cited for: PROTEIN SEQUENCE OF 2-10; 62-72; 79-97 AND 166-186, FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH RNF138.Ref.12"E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system."_x005F_x005F_x000D_Flierman D., Coleman C.S., Pickart C.M., Rapoport T.A., Chau V._x005F_x005F_x000D_Proc. Natl. Acad. Sci. U.S.A. 103:11589-11594(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN DEGRADATION OF MHC CLASS I HEAVY CHAINS.Ref.13"E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages."_x005F_x005F_x000D_Christensen D.E., Brzovic P.S., Klevit R.E._x005F_x005F_x000D_Nat. Struct. Mol. Biol. 14:941-948(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN POLYUBIQUITINATION, INTERACTION WITH BRCA1.Ref.15"The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."_x005F_x005F_x000D_David Y., Ziv T., Admon A., Navon A._x005F_x005F_x000D_J. Biol. Chem. 285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY.Ref.16"Destabilization of Rb by human papillomavirus E7 is cell cycle dependent: E2-25K is involved in the proteolysis."_x005F_x005F_x000D_Oh K.J., Kalinina A., Bagchi S._x005F_x005F_x000D_Virology 396:118-124(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN VIRUS-INDUCED DEGRADATION OF RB1. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.057 ng/mL

Description: Recombinant Human Ubiquitin-conjugating enzyme E2 K(UBE2K) expressed in E.coli