Segregation and potential functional impact of a rare stop-gain PABPC4L variant in familial atypical Parkinsonism.

Atypical parkinsonian problems (APDs) comprise a group of neurodegenerative ailments with heterogeneous scientific and pathological options. Most APDs are sporadic, however rare familial kinds have additionally been reported.

Epidemiological and autopsy research related APDs with oxidative stress and mobile protein aggregates. Identifying molecular mechanisms that translate stress into poisonous protein aggregation and neurodegeneration in APDs is an energetic space of analysis. Recently, ribonucleic acid (RNA) stress granule (SG) pathways had been mentioned to be pathogenically related in a number of neurodegenerative problems together with APDs.

Using entire genome sequencing, mRNA expression evaluation, transfection assays and cell imaging, we investigated the genetic and molecular foundation of a familial neurodegenerative atypical parkinsonian dysfunction. We investigated a household with six dwelling members in two generations exhibiting scientific signs in step with atypical parkinsonism. Two affected relations suffered from parkinsonism that was related to ataxia. Magnetic resonance imaging (MRI) of these sufferers confirmed brainstem and cerebellar atrophy.

Whole genome sequencing recognized a heterozygous stop-gain variant (c.C811T; p.R271X) in the Poly(A) binding protein, cytoplasmic 4-like (PABPC4L) gene, which co-segregated with the illness in the household. In situ hybridization confirmed that the murine pabpc4l is expressed in a number of mind areas and in explicit in the cerebellum and brainstem.

To decide the functional impact of the stop-gain variant in the PABPC4L gene, we investigated the subcellular localization of PABPC4L in heterologous cells. Wild-type PABPC4L protein localized predominantly to the cell nucleus, in distinction to the truncated protein encoded by the stop-gain variant p.R271X, which was discovered homogeneously all through the cell. Interestingly, the wild-type, however not the truncated protein localized to RasGAP SH3 area Binding Protein (G3BP)-labeled cytoplasmic granules in response to oxidative stress induction.

Segregation and potential functional impact of a rare stop-gain PABPC4L variant in familial atypical Parkinsonism.
Segregation and potential functional impact of a rare stop-gain PABPC4L variant in familial atypical Parkinsonism.

Tubulin beta 3 / TUBB3 (Neuronal & Stem Cell Marker)(TUBB3/3731), 1mg/mL

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EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Tubulin beta 3 / TUBB3 (Neuronal & Stem Cell Marker)(TUBB3/3732), 1mg/mL

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EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Tubulin beta 3 / TUBB3 (Neuronal & Stem Cell Marker)(TUBB3/3731), CF568 conjugate, 0.1mg/mL

BNC683731-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Tubulin beta 3 / TUBB3 (Neuronal & Stem Cell Marker)(TUBB3/3731), CF568 conjugate, 0.1mg/mL

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Tubulin beta 3 / TUBB3 (Neuronal & Stem Cell Marker)(TUBB3/3732), CF568 conjugate, 0.1mg/mL

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Tubulin beta 3 / TUBB3 (Neuronal & Stem Cell Marker)(TUBB3/3731), CF647 conjugate, 0.1mg/mL

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
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EUR 532
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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Tubulin beta 3 / TUBB3 (Neuronal & Stem Cell Marker)(TUBB3/3731), Biotin conjugate, 0.1mg/mL

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Tubulin beta 3 / TUBB3 (Neuronal & Stem Cell Marker)(TUBB3/3731), CF640R conjugate, 0.1mg/mL

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Tubulin beta 3 / TUBB3 (Neuronal & Stem Cell Marker)(TUBB3/3732), CF640R conjugate, 0.1mg/mL

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Tubulin beta 3 / TUBB3 (Neuronal & Stem Cell Marker)(TUBB3/3732), CF640R conjugate, 0.1mg/mL

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EUR 532
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Tubulin beta 3 / TUBB3 (Neuronal & Stem Cell Marker)(TUBB3/3732), CF405S conjugate, 0.1mg/mL

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 238.8
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EUR 238.8
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CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496) Antibody

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EUR 652.8
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496),CF680R conjugate, Concentration: 0.1mg/mL

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EUR 238.8
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EUR 652.8
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496),CF555 conjugate, Concentration: 0.1mg/mL

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EUR 238.8
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CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496) Antibody

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EUR 652.8
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496),CF660R conjugate, Concentration: 0.1mg/mL

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EUR 238.8
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496),CF543 conjugate, Concentration: 0.1mg/mL

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EUR 652.8
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496),CF543 conjugate, Concentration: 0.1mg/mL

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EUR 238.8
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EUR 652.8
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EUR 459.6
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EUR 652.8
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EUR 238.8
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EUR 652.8
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EUR 459.6
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EUR 459.6
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CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), 0.2mg/mL

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), 0.2mg/mL

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), 1mg/mL

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EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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EUR 486
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CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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EUR 279.6
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF770 conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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EUR 654
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF770 conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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EUR 279.6
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF680 conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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EUR 654
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF680 conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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EUR 279.6
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF680R conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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EUR 654
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF680R conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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EUR 279.6
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF555 conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF555 conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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EUR 279.6
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF660R conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF660R conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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EUR 279.6
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF543 conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

BNC432217-500 500uL
EUR 654
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF543 conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

BNC052217-100 100uL
EUR 279.6
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF405M conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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EUR 654
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF405M conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

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EUR 472.8
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CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

BNCAP2217-100 100uL
EUR 279.6
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

BNCAP2217-500 500uL
EUR 654
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

BNCH2217-100 100uL
EUR 279.6
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

BNCH2217-500 500uL
EUR 654
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

BNCP2217-250 250uL
EUR 472.8
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), PerCP conjugate, Concentration: 0.1mg/mL

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R) Antibody

BNCR2217-250 250uL
EUR 472.8
Description: Primary antibody against CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), RPE conjugate, Concentration: 0.1mg/mL

HighQC™ Human Neuronal Stem Cell (Hippocampus Derived)

ABC-SC2097 1 vial Ask for price
Description: The Human Neuronal Stem Cells (Hippocampus) was derived from Adult Human Brain (Hippocampus). They were maintained in Gentaur's Human Neuronal Stem Cells (Hippocampus)Complete Growth Medium and sub-cultured every 24 to 48 hours on Human Neuronal Stem Cells (Hippocampus) Extracellular Matrix

Rabbit Polyclonal Antibody against UCHL1 (PGP9.5) - Neuronal Marker - Neuronal Marker

TA301477 100 µl Ask for price

Anti-CD56 / NCAM1 (Neuronal Cell Marker) Monoclonal Antibody

M00184 100ug/vial
EUR 476.4
Description: Mouse Monoclonal CD56 / NCAM1 (Neuronal Cell Marker) Antibody. Validated in Flow Cytometry and tested in Human, Rat, Zebrafish.

HighQC™ Human Neuronal DA Progenitor Stem Cell

ABC-SC0074 1 vial Ask for price
Description: Human Neuronal DA Progenitor Stem Cells; Frozen Vial and Plated cells are available. Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

Tau (Neuronal Marker), Antibody

GWB-BE5100 7 ml Ask for price

Tau (Neuronal Marker), Antibody

GWB-C2FE50 1 ml Ask for price

HighQC™ Rat Superior Mesenteric Plexus Neuronal Stem Cell

ABC-SC0001 1 vial Ask for price
Description: Rat Superior Mesenteric Plexus Neuronal Stem Cells; Frozen Vial and Plated cells are available. Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

HighQC™ Rat Inferior Mesenteric Plexus Neuronal Stem Cell

ABC-SC0015 1 vial Ask for price
Description: Rat Inferior Mesenteric Plexus Neuronal Stem Cells; Frozen Vial and Plated cells are available. Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker); Clone 123C3.D5 (Concentrate)

RA0237-C.1 0.1 ml
EUR 60.07

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker); Clone 123C3.D5 (Concentrate)

RA0237-C.5 0.5 ml
EUR 200.66

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker); Clone NKH1/784 (Concentrate)

RA0240-C.1 0.1 ml
EUR 60.07

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker); Clone NKH1/784 (Concentrate)

RA0240-C.5 0.5 ml
EUR 200.66

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker); Clone NKH1/795 (Concentrate)

RA0241-C.1 0.1 ml
EUR 60.07

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker); Clone NKH1/795 (Concentrate)

RA0241-C.5 0.5 ml
EUR 200.66

Monoclonal CD56 / NCAM1 (Neuronal Cell Marker) Antibody, Clone: SPM128

APG03047G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD56 / NCAM1 (Neuronal Cell Marker). The antibodies are raised in Mouse and are from clone SPM128. This antibody is applicable in IHC, IF, FC

HighQC™ Mouse Superior Mesenteric Plexus Neuronal Stem Cell

ABC-SC0026 1 vial Ask for price
Description: Mouse Superior Mesenteric Plexus Neuronal Stem Cells; Frozen Vial and Plated cells are available. Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

HighQC™ Mouse Inferior Mesenteric Plexus Neuronal Stem Cell

ABC-SC0039 1 vial Ask for price
Description: Mouse Inferior Mesenteric Plexus Neuronal Stem Cells; Frozen Vial and Plated cells are available. Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

HighQC™ Human Superior Mesenteric Plexus Neuronal Stem Cell

ABC-SC0058 1 vial Ask for price
Description: Human Superior Mesenteric Plexus Neuronal Stem Cell; Frozen Vial and Plated cells are available. Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

HighQC™ Human Inferior Mesenteric Plexus Neuronal Stem Cell

ABC-SC0092 1 vial Ask for price
Description: Human Inferior Mesenteric Plexus Neuronal Stem Cell; Frozen Vial and Plated cells are available. Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

HighQC™ Rat Neuronal (Trans-Differentiated) Stem Cell

ABC-SC0006 1 vial Ask for price
Description: Rat Neuronal cells trans-differentiated Stem Cells; Frozen Vial and Plated cells are available. Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker); Clone 123A8 (56C04) (Concentrate)

RA0238-C.1 0.1 ml
EUR 60.07

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker); Clone 123A8 (56C04) (Concentrate)

RA0238-C.5 0.5 ml
EUR 200.66

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker); Clone 123C3.D5 & 123A8 (Concentrate)

RA0239-C.1 0.1 ml
EUR 60.07

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker); Clone 123C3.D5 & 123A8 (Concentrate)

RA0239-C.5 0.5 ml
EUR 200.66

Monoclonal CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody, Clone: SPM489

AMM05475G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD56 / NCAM1 / NKH1 (Neuronal Cell Marker). The antibodies are raised in Mouse and are from clone SPM489. This antibody is applicable in IHC, IF

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), CF568 conjugate, 0.1mg/mL

BNC681496-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), CF568 conjugate, 0.1mg/mL

BNC681496-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), CF568 conjugate, 0.1mg/mL

BNC681602-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), CF568 conjugate, 0.1mg/mL

BNC681602-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), CF647 conjugate, 0.1mg/mL

BNC471496-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), CF647 conjugate, 0.1mg/mL

BNC471496-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), CF647 conjugate, 0.1mg/mL

BNC471602-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), CF647 conjugate, 0.1mg/mL

BNC471602-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), CF594 conjugate, 0.1mg/mL

BNC941496-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), CF594 conjugate, 0.1mg/mL

BNC941496-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), CF594 conjugate, 0.1mg/mL

BNC941602-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), CF594 conjugate, 0.1mg/mL

BNC941602-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Monoclonal CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody, Clone: 123C3.D5

APR11294G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD56 / NCAM1 / NKH1 (Neuronal Cell Marker). The antibodies are raised in Mouse and are from clone 123C3.D5. This antibody is applicable in IHC, IF, FC

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF568 conjugate, 0.1mg/mL

BNC682217-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF568 conjugate, 0.1mg/mL

BNC682217-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), CF488A conjugate, 0.1mg/mL

BNC881496-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), CF488A conjugate, 0.1mg/mL

BNC881496-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), CF488A conjugate, 0.1mg/mL

BNC881602-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), CF488A conjugate, 0.1mg/mL

BNC881602-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF647 conjugate, 0.1mg/mL

BNC472217-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF647 conjugate, 0.1mg/mL

BNC472217-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), CF405S conjugate, 0.1mg/mL

BNC041496-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), CF405S conjugate, 0.1mg/mL

BNC041496-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), CF405S conjugate, 0.1mg/mL

BNC041602-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), CF405S conjugate, 0.1mg/mL

BNC041602-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), CF640R conjugate, 0.1mg/mL

BNC401496-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), CF640R conjugate, 0.1mg/mL

BNC401496-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), CF640R conjugate, 0.1mg/mL

BNC401602-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), CF640R conjugate, 0.1mg/mL

BNC401602-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), Biotin conjugate, 0.1mg/mL

BNCB1496-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/1496), Biotin conjugate, 0.1mg/mL

BNCB1496-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), Biotin conjugate, 0.1mg/mL

BNCB1602-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(ERIC-1), Biotin conjugate, 0.1mg/mL

BNCB1602-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF594 conjugate, 0.1mg/mL

BNC942217-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF594 conjugate, 0.1mg/mL

BNC942217-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Monoclonal CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody, Clone: NCAM1/784

APG03050G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD56 / NCAM1 / NKH1 (Neuronal Cell Marker). The antibodies are raised in Mouse and are from clone NCAM1/784. This antibody is applicable in IHC, IF, FC

Monoclonal CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody, Clone: NCAM1/795

APR11293G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD56 / NCAM1 / NKH1 (Neuronal Cell Marker). The antibodies are raised in Mouse and are from clone NCAM1/795. This antibody is applicable in WB, IHC and IF, FC

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF488A conjugate, 0.1mg/mL

BNC882217-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF488A conjugate, 0.1mg/mL

BNC882217-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF405S conjugate, 0.1mg/mL

BNC042217-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF405S conjugate, 0.1mg/mL

BNC042217-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF640R conjugate, 0.1mg/mL

BNC402217-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), CF640R conjugate, 0.1mg/mL

BNC402217-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), Biotin conjugate, 0.1mg/mL

BNCB2217-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) (NCAM1/2217R), Biotin conjugate, 0.1mg/mL

BNCB2217-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Monoclonal CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody, Clone: 123C3.D5 + 123A8

AMM05474G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD56 / NCAM1 / NKH1 (Neuronal Cell Marker). The antibodies are raised in Mouse and are from clone 123C3.D5 + 123A8. This antibody is applicable in IHC, IF, FC

Monoclonal CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody, Clone: 123A8; same 56C04

AMM05476G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD56 / NCAM1 / NKH1 (Neuronal Cell Marker). The antibodies are raised in Mouse and are from clone 123A8; same 56C04. This antibody is applicable in IHC, IF

Monoclonal CD56 / NCAM1 (Neuronal Cell Marker) Antibody - With BSA and Azide, Clone: SPM128

APG03048G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD56 / NCAM1 (Neuronal Cell Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone SPM128. This antibody is applicable in IHC-P, IF, FC

Neurofilament (H+L) (Neuronal Marker)(2F11), 0.2mg/mL

BNUB3912-100 1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Neurofilament (H+L) (Neuronal Marker)(2F11), 0.2mg/mL

BNUB3912-500 1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Neurofilament (H+L) (Neuronal Marker)(2F11), 1mg/mL

BNUM3912-50 1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Monoclonal CD56 / NCAM1 (Neuronal Cell Marker) Antibody - Without BSA and Azide, Clone: SPM128

APG03049G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD56 / NCAM1 (Neuronal Cell Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone SPM128. This antibody is applicable in IHC-P, IF, FC

Neurofilament (NF-H) (Neuronal Marker) (rNF421) Antibody

BNUB2348-50 50uL
EUR 486
Description: Primary antibody against Neurofilament (NF-H) (Neuronal Marker) (rNF421), 1mg/mL

Neurofilament (NF-H) (Neuronal Marker) (rNF421) Antibody

BNC702348-100 100uL
EUR 279.6
Description: Primary antibody against Neurofilament (NF-H) (Neuronal Marker) (rNF421), CF770 conjugate, Concentration: 0.1mg/mL

Neurofilament (NF-H) (Neuronal Marker) (rNF421) Antibody

BNC702348-500 500uL
EUR 654
Description: Primary antibody against Neurofilament (NF-H) (Neuronal Marker) (rNF421), CF770 conjugate, Concentration: 0.1mg/mL

This means that the PABPC4L variant alters intracellular distribution and presumably the stress granule related operate of the protein, which can underlie APD in this household. In conclusion, we current genetic and molecular proof supporting the function of a stop-gain PABPC4L variant in a rare familial APD. Our information exhibits that the variant outcomes in mobile mislocalization and incapacity of the protein to affiliate with stress granules.

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